Doomsday in Denver?
It certainly felt that way for the New York Knicks.
Anthony left the game in the third quarter due to a sore right knee, the same injury that kept him out of three straight games last week.
Chandler left the game late in the first half with a left knee contusion.
It is unclear if either player will be available for Thursday's game against Portland.
As far as what happened on the court, the Nuggets went on a 17-0 run in the second quarter and never looked back, literally running the Knicks out of the Pepsi Center.
New York has lost the first two games of its season-long five-game road trip.
The Knicks are a game behind Indiana for second place in the East and 1½ games up on Brooklyn for the top spot in the Atlantic Division.
UNHAPPY HOMECOMING: Nothing really went well for Melo in his Denver homecoming.
He scored nine points on 3-for-12 shooting and had five rebounds and three turnovers.
Anthony left the game early in the third quarter with a sore right knee.
He returned to the floor on Monday night after missing the previous three games due to the ailment, but he clearly isn't himself.
Anthony went 4-for-15 and scored 14 points in the Knicks' blowout loss to Golden State on Monday.
It is unclear if Anthony will play Thursday against the Blazers.
He returned to Denver Wednesday for the first time since he requested a trade to New York in 2010-11.
The Nuggets have gone 99-57 in the regular season since the trade, with many of the players they acquired in the transaction; the Knicks are 88-68 with Anthony.
Fans at the Pepsi Center at one point chanted, "Who needs Melo?" during the blowout.
CHANDLER'S INJURY: The Knicks are already besieged by injuries to key players (Anthony, Amar'e Stoudemire).
They can ill afford to be without Chandler for an extended period.
Chandler crumpled to the floor late in the second quarter after bumping knees with Denver's Corey Brewer.
He walked off the court with help from his teammates and the Knicks say he has a contusion of his left knee.
If that's true, it's good news for Mike Woodson's club. Chandler suffered a bone bruise on his left knee in the Knicks' last preseason game and was well enough to play in the season opener.
The first-time All-Star has played in every game this season.
RUN OFF THE FLOOR: One of the Knicks' goals coming into the game was to slow the Nuggets down.
The Nuggets had 20 fast-break points and 22 points off of 19 Knicks turnovers.
They scored 62 points in the paint, compared to just 24 for the Knicks. New York was outrebounded 53-33.
Former Knicks Wilson Chandler (24) and Danilo Gallinari (16) led the way for the Nuggets. The lone bright spot for the Knicks? Twenty points from Iman Shumpert. Shumpert went 8-for-10 from the floor and hit four of his five 3-point attempts.
WHAT'S NEXT: The Knicks take on the Portland Trail Blazers in the second game of a back-to-back and the third game of their season-long five-game road trip. The road trip wraps up with a back-to-back against the Los Angeles Clippers and Utah Jazz on Sunday and Monday, respectively.
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