With Raymond Felton (hamstring) already hurt, that leaves the Knicks with few options at point guard.
Here is a look at what New York may do to replace Prigioni:
Players already on the roster: The Knicks can turn to Beno Udrih to start at point guard. But the veteran may not be conditioned well enough to play 35-40 minutes a night.
Woodson mentioned that he'd give rookie Toure' Murry a look as well. Murry had a solid showing in training camp and is viewed as a strong athlete who has the lateral quickness and length to guard the position well.
Woodson also said that Iman Shumpert will play some point guard.
Lastly, there is a possibility that the Knicks will call up Chris Smith, J.R.'s younger brother, from New York's D League affiliate, the Erie BayHawks.
Trade market: Prior to Monday's game, two league sources told ESPN New York that talks between the Raptors and Knicks regarding Kyle Lowry had quieted down.
Could Prigioni's injury change that?
One league source with knowledge of the talks said prior to Monday's game that the Knicks weren't interested in dealing Tim Hardaway Jr. or a first-round pick to Toronto for Lowry, who is a free agent after this season.
But Prigioni's injury may force them to rethink their stance.
Free agency: There are players such as Sebastian Telfair, Delonte West and Mike James who are available. But the Knicks would need to cut a player to make room for a free-agent signee.
Question: How would you like to see the Knicks fill the void left by Prigioni?
You can follow Ian Begley on Twitter.