The Padres nonetheless remain the lone major league franchise lacking the pitching feat.
Yoenis Cespedes delivered the first hit against Padres right-hander Colin Rea with a two-out single in the seventh. The Mets ultimately opened their 11-game trip with a 5-3 loss on Thursday night at Petco Park.
Cespedes delivered the shot through the vacated right side of the infield with the Padres (12-17) heavily shifting the righty hitter. San Diego had benefited throughout the game from pronounced shifts against the Mets' lefty hitters.
Rea, a 12th-round pick in 2011 out of Indiana State University, took a shutout bid into the ninth. He departed after a leadoff homer by Curtis Granderson. He allowed one run on three hits and one walk in a career-high eight innings. His no-hit bid lasted into the latter innings in large part thanks to center fielder Jon Jay's third-inning grab. Jay raced to the warning track in left-center and made a sliding catch to rob Granderson of a hit. The Mets' second hit against Rea (3-1) came on Kevin Plawecki's two-out single in the eighth. After Rea departed, Cespedes launched a two-run homer in the ninth against Brad Hand.
The Mets have quite the history in San Diego of nearly getting no-hit. Rea's bid was the longest by a Padre since Odrisamer Despaigne held the Mets hitless for 7 2/3 innings on July 20, 2014. David Wright broke up that no-hit bid with a game-tying RBI single in the eighth, although the Mets eventually lost 2-1.
Then there was July 21, 1970, at old San Diego Stadium. Although leading 1-0 entering the ninth, the Mets were getting no-hit by Clay Kirby. The Mets then produced three hits in the ninth against Jack Baldschun en route to a 3-0 win.
The Padres remain no-hitter-less in 7,519 games in franchise history. The Mets, who had been the second-to-last franchise without a no-hitter, ended their 8,019-game futility on June 1, 2012 with Johan Santana's no-hitter.
Meanwhile, Jacob deGrom (3-1) allowed three runs on eight hits and a walk in five innings en route to his first loss. The damage included a first-inning solo homer from Wil Myers and a two-out RBI single in the second by Rea. The only other RBI hit surrendered to a pitcher in deGrom's career had been a homer by the Cubs' Travis Wood on June 5, 2014. The Padres added two runs in the sixth against Logan Verrett -- the latter scoring on a throwing error by left fielder Michael Conforto.
What's next: Noah Syndergaard (2-1, 2.51 ERA) opposes left-hander Drew Pomeranz on Friday at 10:40 p.m. ET. Syndergaard will look to speed up his delivery after the Cincinnati Reds and San Francisco Giants combined to steal eight bases in eight attempts against him in his past two starts.