Rapid Reaction: Brewers 5, Mets 2

MILWAUKEE -- Starting pitcher Jonathon Niese’s first outing since coming off the disabled list was rocky. This one was better, but still not good enough as the New York Mets lost 5-2 to the Milwaukee Brewers on Saturday night.

Coming back from left shoulder inflammation, his first start ended with season-highs -- the bad kind -- in hits (11) and runs (4) over six innings in a 5-2 loss to the Seattle Mariners on Monday.

The left-hander’s chances to rebound against the Brewers certainly looked promising. He came in 2-0 with a 4.64 ERA in six career starts against them, but ended up losing after allowing three runs on five hits with two walks and four strikeouts over five innings.

Niese (5-6) cruised through the first four innings, but then came unglued with two out in the bottom of the fifth when Milwaukee pushed across three runs to take the lead.

Niese’s wild pitch allowed Jean Segura to score from third. Carlos Gomez followed with a single and scored on Jonathan Lucroy’s double, who then scored on Ryan Braun’s base hit.

The Mets had plenty of chances to help Niese in a close game, but failed to come up with any timely hits. They were 1 for 11 with runners in scoring position and stranded nine.

Both managers changed pitchers simultaneously with two out in the top of the sixth.

With a runner at third, Terry Collins sent Bobby Abreu to pinch hit for Niese, but Brewers manager Ron Roenicke pulled starter Wily Peralta (12-6) and brought on Zach Duke. Collins then countered by bringing Abreu back into the dugout and sending out Eric Campbell. Duke struck out Campbell to end the threat and preserve a 3-2 lead for Peralta.

Carlos Torres relieved Niese to start the bottom of the sixth. Mark Reynolds greeted him with a solo home run that upped Milwaukee’s lead to 4-2.

Milwaukee tacked on another run off Torres with two out in their half of the eighth, when Rickie Weeks singled and scored on a double by Khris Davis. Reynolds hit a roller to third that David Wright fielded and threw to first in a close play. Initially ruled safe with another run scoring, manager Terry Collins asked for a review for the third consecutive game. After a one minute, three second study, the safe call was reversed.

Just dandy: Granderson finally delivered what the Mets needed from their lead-off hitter.

Batting first for the 26th time this season, he flew out to right field, extending his futility streak to 0-for-18. But, in the third, he doubled leading off the frame and scored on a one-out bloop single by Lucas Duda. In the fifth, he led off with a solo shot just inside the right-field foul pole for his 15th home run. His first since July 8.

Murphy’s bat: Friday night, Daniel Murphy went 3-for-4. Saturday night, he came in tied for third in the NL with 121 hits. That total went up with a 2-for-4 effort.

What’s next: Right-hander Jacob deGrom (4-5, 3.01 ERA) gets his second shot at the Brewers this season after they beat him 3-1 on June 11 at Citi Field. Right-hander Jimmy Nelson (1-1, 5.06) goes for Milwaukee in the 2:10 p.m. finale of the four-game series.