Jeter is out for the rest of the playoffs after fracturing his left ankle in the 12th inning of New York’s 6-4 loss to Detroit in Game 1 of the ALCS on Saturday night.
Nix will be batting ninth in the lineup.
“The bottom line is that Derek’s down and I’m in, so it’s an opportunity for me, it’s time for me to do what I can do, and I’m excited for it,” Nix said Saturday night.
Yankees manager Joe Girardi has made several other changes to lineup to try and get things jumpstarted.
Second baseman Robinson Cano, who is 0 for his last 22, has been moved up to the No. 2 slot in the batting order.
Right fielder Nick Swisher, marred in a 1-for-16 slide, has been dropped down to eighth.
Third baseman Alex Rodriguez, who is hitting .105 in the postseason, will once again hit sixth.
Center fielder Curtis Granderson, who has struck out 11 times in 23 postseason at-bats, will hit seventh.
Raul Ibanez will serve as the designated hitter and bat in the cleanup spot. Ibanez hit another game-tying, ninth-inning, two-out homer on Saturday night.
Left fielder Ichiro Suzuki will leadoff in place of Jeter.
Cano, Swisher, A-Rod and Granderson are hitting a combined .108 (10-for-93) in the postseason.
Sunday’s lineup that will face Tigers right-hander Anibal Sanchez:
Ichiro Suzuki LF
Robinson Cano 2B
Raul Ibanez DH
Alex Rodriguez 3B
Curtis Granderson CF
Nick Swisher RF
Jayson Nix SS
Hiroki Kuroda, RHP