Rapid Reaction: Orioles 6, Yankees 3

WHAT IT MEANS: The Yankees lose two of three to the Orioles, but, more importantly, Hiroki Kuroda had to leave the game with an injury. The initial report is a bruised calf.

NOW WHAT: The Yankees have suffered an incredible amount of injuries and have overcome every single one of them. Their pitching has led them throughout their hot start, beginning with Kuroda, who has been an ace. If he joins Andy Pettitte and Ivan Nova on the disabled list, the Yankees will have a challenge in trying to continue their torrid pace. We should find out more about the injury in the postgame.

CY WHAT: Even before the injury, the Orioles were not impressed with Kuroda's sensational start. After two outs in the first, Nick Markakis hit a solo shot and Chris Davis nailed a two-run homer to make it 3-0.

Matt Wieters doubled before Kuroda finally recorded the third out on a J.J. Hardy fly out.

THEY HIT HIM HARD -- LITERALLY: After mashing Kuroda in the first, Manny Machado crushed a liner off Kuroda's right leg. Kuroda would record the last out of the second. In the third, he would be lifted following a single and a double.

FINAL LINE: Kuroda lasted two innings and gave up five runs on eight hits. It didn't help that when he left, Preston Claiborne gave up a three-run homer to Wieters.

GRANDY MAN CAN: With open tryouts for the outfield spots having begun, Curtis Granderson made his presence felt. In his first three at-bats, Granderson had a double, a single and a solo homer. In his fourth at-bat, he walked.

Manager Joe Girardi, displaying clairvoyance, said Wednesday night that Granderson was "coming around" and that he was about ready to "take off." A very good call by "The Binder," as those were the first extra-base hits for Granderson in his seven-game return.

WARREN DELIVERS: Adam Warren quietly is duplicating the job David Phelps did in 2012. In the long man role, he added another four scoreless innings. His ERA is down to 1.14 in 23 2/3 innings.

DAVID DINGER: In the ninth, David Adams hit his second career homer and second of the series, with a solo shot to lead off the inning.

STAT OF THE NIGHT: Davis is the first Orioles lefty to go 4-for-4 or better with a homer versus the Yankees since Boog Powell in 1962, according to ESPN researcher Katie Sharp.