Wolff missed four games after injuring his right knee in Green Bay Nov. 10. He returned for last week's game against Chicago but left after playing one series. Veteran Patrick Chung will start at safety in place of the rookie.
Backup safety Colt Anderson (hamstring) and backup center Julian Vandervelde, who were listed as out, were both inactive. Otherwise, it was the usual group: quarterback Matt Barkley, running back Matthew Tucker, offensive lineman Dennis Kelly and cornerback Curtis Marsh.
Offensive lineman Matt Tobin is active for the second time this season. He takes Vandervelde's spot on the 46-man roster, but would not play center if anything happened to starter Jason Kelce. That role would likely fall to left guard Evan Mathis.