Willis, McDonald ready to go

SAN FRANCISCO -- Patrick Willis is an active San Francisco 49er again.

The star inside linebacker is expected to start. He hasn’t played since Week 3 against the Colts when he suffered a groin injury.

Defensive lineman Ray McDonald is also active as expected. He suffered a biceps injury last week and did not practice Wednesday and Thursday. But the team doesn’t think he is at risk of suffering further damage to the bicep if he continues to play.

Cornerback Nnamdi Asomugha and running back LaMichael James are healthy but still not active. Asomugha lost his No. 3 cornerback job when Tramaine Brock played well the past two weeks while Asomugha was out with a knee injury.

James missed the first three games with a knee injury. But the 2012 second-round pick did play the past two weeks. There have been signs that the team is not confident in James in pass protection. Thus, he may have a difficult time getting back on the field.

Asomugha and James potentially could be in danger when the 49ers starting bringing back several players from injured lists in the coming weeks.

Meanwhile, CBS Sports is reporting that the 49ers have interest in Giants’ receiver Hakeem Nicks. It makes sense the 49ers are in need of a receiver and they have been also linked to the Browns’ Josh Gordon and the Titans’ Kenny Britt. The trade deadline is Oct. 29.

Tampa Bay signed guard Patrick Omameh off the 49ers’ practice squad. They now have an opening on the eight-player squad.