Receivers Mario Manningham and Hakeem Nicks are both active despite injuries. How well they hold up will be the next big question. The 49ers' secondary has been a hard-hitting group this season. Their secondary has also been vulnerable, at times, against the best quarterbacks it has faced, notably Tony Romo and Michael Vick.
The Giants will be without running back Ahmad Bradshaw, as expected. Their full list of inactive players Sunday: receiver Jerrell Jernigan, cornerback Prince Amukamara, Bradshaw, fullback Henry Hynoski, guard Mitch Petrus, defensive tackle Dwayne Hendricks and tackle James Brewer.
The 49ers' list carried little suspense. Defensive end Ray McDonald is active, though it's unclear whether he'll start after missing Week 9 with a hamstring injury. Quarterback Scott Tolzien, cornerback Shawntae Spencer, offensive lineman Mike Person, offensive lineman Daniel Kilgore, fullback Moran Norris, receiver Brett Swain and nose tackle Ian Williams are inactive.