How much should 49ers be concerned?

The San Francisco 49ers locked down the No. 2 seed in the NFC playoffs with their victory over the St. Louis Rams in Week 17.

They finished their first season under coach Jim Harbaugh with a 13-3 record. They earned a first-round playoff bye.

The 49ers also struggled late in the game Sunday and had to hold on for a a 34-27 victory. They have lost key players to injuries. Their defense has faltered over the last couple weeks.

I'd like to use your thoughts for a Monday item. How worried should the 49ers be heading toward the playoffs? Thanks in advance.