The upside: Even the worst defeats tend to feature a bright spot or two.
The Cardinals emerged with the seventh pick in the 2013 draft behind Kansas City, Jacksonville, Oakland, Philadelphia, Detroit and Cleveland.
Kicker Jay Feely made both field goal tries.
Arizona led the game, 6-0.
The Cardinals allowed only two sacks. They held the 49ers' Aldon Smith without a sack, preventing Smith from challenging the single-season record for sacks.
Calais Campbell collected another sack, giving him one in each of the Cardinals' final three games and 6.5 for the season.
Arizona held Frank Gore to 3.4 yards per carry and a long run of 9 yards.
Rookie Michael Floyd caught eight passes for 166 yards and a 37-yard touchdown.
The Cardinals held the 49ers to 29 percent on third-down conversions.
Looking ahead: The Cardinals have yet to announce potential changes to their front office or coaching staff.