Playing without Williams, in particular, puts the Seahawks at a significant deficit as they try to improve their NFC West record to 4-1 against the San Francisco 49ers at Candlestick Park. Williams' presence on third down, in particular, helps the Seahawks sustain drives. Quarterback Matt Hasselbeck has played at a higher level lately -- more confidently, more efficiently -- with Williams in the lineup.
Seattle might now need to rely more heavily on its ground game. The ground game showed improvement against Carolina last week. The 49ers are allowing 3.6 yards per carry on the ground, however. That is the third-best average for any defense in the NFL this season.
Also inactive for Seattle: guard Breno Giacomini, guard Chester Pitts, tackle William Robinson, defensive lineman Amon Gordon and defensive lineman Jay Richardson. J.P. Losman is the third quarterback.
The 49ers' inactive players: kicker Joe Nedney, cornerback Tramaine Brock, running back DeShawn Wynn, cornerback William James, linebacker Thaddeus Gibson, tackle Joe Staley and tackle Alex Boone. David Carr is the third quarterback.