Nicks is traveling Monday to Santa Clara, according to ESPN’s Josina Anderson.
A six-year veteran who was the No. 29 overall pick of the 2009 draft, Nicks had 1,000-yard receiving seasons for the New York Giants in 2010 and 2011. He signed with Indianapolis last year, envisioning becoming the Colts’ No. 3 receiver behind Reggie Wayne and T.Y. Hilton.
But Nicks, 27, struggled and fell to No. 4 on the Colts’ WR depth chart, finishing with a career-low 38 catches for a career-worst 405 yards. He did, however, have four touchdown catches. He was the fifth receiver drafted in 2009, behind Darrius Heyward-Bey, Michael Crabtree, Jeremy Maclin and Percy Harvin.
Earlier this offseason, the Niners signed receiver Torrey Smith to be their deep threat, along with Jerome Simpson. Smith, a second-rounder in the 2011 draft, 12-year veteran Anquan Boldin and Simpson, who may face a suspension to start the season, are the only receivers on the 49ers’ roster with at least six career catches.
Crabtree remains unsigned as a free agent, though Niners general manager Trent Baalke said last week at the NFL owners meetings that the 49ers’ first-round pick from 2009 was still on the table, so to speak.
ESPN NFL Nation Colts reporter Mike Wells contributed to this report.