The upside: Even the worst defeats tend to feature a bright spot or two.
The 49ers remain atop the NFC West, ahead of the Seahawks.
San Francisco can clinch its second consecutive division title with a victory or tie Sunday, or with less than a victory for Seattle.
The 49ers can clinch a first-round bye with a victory if Green Bay loses.
Rookie LaMichael James set a career high with 201 total yards: 172 on returns, 15 rushing and 14 receiving.
Patrick Willis collected his second interception of the season.
Delanie Walker caught a touchdown pass for the third time this season.
Colin Kaepernick completed 6 of 9 passes for 95 yards (10.6 per attempt) during the third quarter.
Looking ahead: The 49ers are home against the Arizona Cardinals in Week 17.