Seahawks' defense without top tackle

Posted by ESPN.com's Mike Sando

SAN FRANCISCO -- Seattle defensive tackle Brandon Mebane's calf injury will prevent him from playing against the 49ers, a significant loss for the Seahawks.

Seattle has good depth on its defensive line. Tackle Red Bryant, a good player, wasn't even active for Week 1. Bryant is active for this game at Candlestick Park.

Inactive for Seattle: Travis Fisher, Leroy Hill, Chris Spencer, Walter Jones, Deion Branch, Mebane and Michael Bennett. There was an extremely slim chance Jones was going to return for this game. I would have been quite surprised, however. Mike Teel is the third quarterback for the Seahawks.

Inactive for the 49ers: Marcus Hudson, Cody Wallace, Brandon Jones, Ricky Jean-Francois, Jason Hill, Ahmad Brooks and Curtis Taylor.