What it means: San Diego recorded its largest margin of victory this season. The Chargers move to 6-7 and are tied with the New York Jets (6-7) and a game behind the Baltimore Ravens (7-6) and Miami Dolphins (7-6) for the final AFC spot with three games to play.
Manning sputters: In his first game back in San Diego since 2005, New York Giants quarterback Eli Manning struggled, finishing 20-of-32 for 259 yards, a touchdown pass and two interceptions. Manning was loudly booed by fans at Qualcomm Stadium when he took the field. Manning, who spurned the Chargers in the 2004 draft, is 0-3 in his 10-year career against San Diego.
Melvin Ingram solid in return: In his first game in nearly a year coming off anterior cruciate ligament knee surgery in May, Ingram unofficially played 13 snaps. Ingram had trouble containing the run a few times and finished with just one tackle. But he left the game healthy, which is the most important thing for the Chargers.
Stock watch: Running back Ryan Mathews gained 103 yards on a season-high 29 carries, as the Chargers controlled the line of scrimmage on both sides of the ball. Mathews eclipsed the 100-yard mark for the fourth time this season.
What’s next: The Chargers travel to Denver for the team’s final road game of the season, a Thursday night contest at Mile High Stadium at 5:25 PT.