SAN FRANCISCO -- Mike Iupati is back.
However, backup receiver Mario Manningham is inactive. He has played the past six games after being out since last December with a knee injury. He missed two days of practice last week with a knee issue and because of an illness. Manningham's play has dwindled in the past three games with star receiver Michael Crabtree back.
Rookie Quinton Patton will get an opportunity. He has played since he broke his foot in Week 4.
Another interesting note about tonight's 46-man roster is tight end Derek Carrier is inactive for first time in a month. Newly signed backup fullback Will Tukuafu is active. He is 293 pounds. He could be a short-yardage factor.