Rapid Reaction: Colts 10, Browns 6

Posted by ESPN.com's James Walker

The Cleveland Browns had another chance to play spoiler to a playoff hopeful and once again failed to pull it off at home. The Mannings improved to 6-1 against the AFC North with a 10-6 victory Sunday at Browns Stadium.

Cleveland tried to execute a game plan of playing ball control on offense to keep the ball out of the hands of Indianapolis quarterback Peyton Manning. It worked for three quarters until a key fourth-quarter fumble was returned 37 yards for a touchdown by Indianapolis lineman Robert Mathis.

But perhaps the biggest loss was the left leg injury to Browns quarterback Derek Anderson, who needed help off the field after being hit by Cleveland lineman Kevin Shaffer and Mathis in what appeared to be a serious knee injury.

Meanwhile, the Browns (4-8) continue their freefall, losing four of their last five. The loss also sealed the third non-winning season under the current regime of general manager Phil Savage and head coach Romeo Crennel.

Following the declaration of Browns owner Randy Lerner last week, it's clear that changes will be made to some degree in an attempt to turn this franchise around in 2009.