Rapid Reaction: 49ers 10, Bills 3

Posted by ESPN.com's Mike Sando

The 49ers showed everything they want to be under Mike Singletary in becoming the first West Coast team to win in the Eastern time zone this season.
Running back Frank Gore ran the ball on the 49ers' first five offensive plays. Quarterback Shaun Hill managed the game and struck downfield selectively. Free-agent addition Justin Smith blew up a fourth-and-2 running play in the fourth quarter when the Bills were threatening to score. And when the Bills needed a comeback late, the 49ers' pass rush took over, with Ray McDonald getting pressure and Smith collecting a key sack.

With the exception of a Gore fumble and an untimely penalty, the 49ers were the smarter team in the second half, letting the Bills make the errors. The Bills were the team suffering from shaky quarterback play, bad decision making and questionable game management.

This marked a reversal for the 49ers and a breakthrough performance for Singletary as he builds a case for keeping the job in 2009.