Readiness factor: The Eagles held a series of player-organized workouts throughout the summer, but quarterback Michael Vick was only there for a couple of days' worth, opting most of the time to work out on his own. They have a new defensive coordinator in Juan Castillo (who was their offensive line coach) and a new defensive line coach in Jim Washburn, so there are likely to be new aspects of the defense they'll have to learn quickly once the coaches can get their hands on them.
Biggest challenge: Constructing that defense. The Eagles need a new cornerback to play alongside Asante Samuel, and they'll probably aim high and try to get Nnamdi Asomugha. It appears as though they're ready to let Quintin Mikell walk, since they appear to think rookie Jaiquawn Jarrett is ready to start right away opposite Nate Allen. But they could add a veteran there to work with the young guys or in case Allen's not fully healthy. They also need to figure out the linebacker situation around potential free agent Stewart Bradley. And Washburn will lobby to add a pass-rushing end and maybe another piece or two along the line. Before the Eagles can set about installing anything new on defense, they'll need to know who the players are who'll be responsible for putting the plans into action.
Vick's backup: The Eagles' first order of post-lockout business is expected to be the trade of backup quarterback Kevin Kolb. Assuming they can get the return for Kolb that most people seem to believe they can (a first-rounder plus, or maybe an established cornerback or linebacker), they'll ship him out of town to Arizona or Seattle or whichever team comes with the best offer. But after that, they'll need to find a veteran quarterback to sit behind Vick and step in if and when the starter gets hurt. Vick has never played a full 16-game season, and his style lends itself to potential injury. And while they like Mike Kafka long-term, he's probably not as ready as Kolb would be to step in and win a game if Vick can't go. Look for the Eagles to explore several possibilities for this role, including the Titans' Vince Young, who might be a perfect fit.