Here are some thoughts on the injury:
It's no secret that this is a big blow for the Jets. New York already had trouble running the football. Mangold anchored the center of the offensive line. In many ways, he was the "quarterback" of that unit. Rookie Colin Baxter is expected to start in Mangold's place Sunday against the Oakland Raiders.
I saw a lot of high-ankle sprains with the Cleveland Browns the past two years, and they're not pretty. There's various degrees of sprains and every player heals differently. But in my experience, two weeks could be generous. Some players with the Browns took about a month to recover. Mangold is very tough and will be pushing to return quickly. New York needs Mangold for the long-term and needs to guard against that, as well.
Mangold is the second starting center in the AFC East to suffer a leg injury. Patriots center Dan Koppen broke his fibula in Week 1 and will be out for a significant period. New England adjusted well Sunday against the San Diego Chargers. The Jets hope they can do the same without Mangold.