Posted by ESPN.com's Tim Graham
Reiss suggested it's commensurate with what New England's offense would encounter if quarterback Tom Brady went down for an extended period.
"You can't replace Jerod," safety James Sanders said. "There is only one Jerod Mayo in the league."
Mayo suffered a right knee injury in the first quarter of Monday night's 25-24 triumph over the Buffalo Bills.
With interviews from the Patriots' locker room and a dissection of how they adjusted personnel-wise after Mayo left the game, Reiss looks for clues as to how the Patriots will cope until the tackling machine gets back.