Williams played two series in the Bills' preseason opener last Sunday, and has been limited throughout training camp with a foot injury.
"He keeps getting treatment to take care of his body," coach Doug Marrone said Wednesday. "Again, we’re just trying to be smart up and down, resting him for some time, just so he can make sure he just gets ready. Especially coming off this short week."
The Bills said Williams will dress for the game, meaning he would be available to play in an emergency.
Other Bills not playing tonight:
WR T.J. Graham
CB Crezdon Butler (will dress)
LB Kiko Alonso (will dress)
Not listed among the inactives are quarterback Kevin Kolb, wide receivers Brad Smith and Kevin Elliott, tight end Scott Chandler, and linebacker Keith Pough. All missed Sunday's win over Indianapolis.