This week, the backup running back has plenty of company on the sideline. Nine San Francisco players -- including quarterback Colin Kaepernick -- landed on the injury list Wednesday. Kaepernick nevertheless practiced fully despite what the team called a foot injury. Neither 49ers coach Jim Harbaugh nor Kaepernick addressed the issues when they spoke to the media prior to practice. If it were serious, Kaepernick wouldn’t have practiced.
Along with James (who has been out for the first two games with a knee injury), tight end Vernon Davis (hamstring) and defensive linemen Justin Smith (shoulder) and Ray McDonald (both ankles) were among the key players who did not practice. There is a solid chance all three play Sunday against the visiting Indianapolis Colts. McDonald might have the most difficult time playing, but there is a chance.