Both almost certainly will get the chance on Sunday against the New England Patriots.
Whether it's a linebacker such as Matthews or a slot cover guy like Hyde – or even a safety or a cornerback – it does not seem to matter. Oh, the Packers will surely try some of all of those combinations, but ...
"I don't know that a lot of people have had great success covering him," Packers defensive coordinator Dom Capers said Friday. "He can go vertical. He's a big guy. He's got a big wing span. You've seen him catch a ball thrown behind him and pull it in. He likes the physical part of the game. He's going to challenge you in terms of tackling. If you go up on his upper body, the guy's big and strong. Tacklers bounce off of him.
"You've got to have a plan to try to get the second and third guy there. He obviously gives them a matchup issue. And then Tom Brady's always aware of who's matched up on him."
After a slow start during which he was working his way back into form following ACL surgery, no tight end in the league has been more productive than Gronkowski. Since Week 5, he has 45 catches for 665 yards and six touchdowns. That's nine more catches and 200 more yards than any other tight end during that span, which encompasses the Patriots' current seven-game winning streak.
None of the Packers' three position coaches – Winston Moss (linebackers), Darren Perry (safeties) and Joe Whitt (cornerbacks) – whose players could conceivably be used in coverage against the Patriots' 6-foot-6, 265-pound tight end -- could identify one type of player who has had the most success defending Gronkowski this season.
Said Moss: "It requires a mindset to where the entire defense has to be ready to handle their assignments."
Said Perry: "No, this guy just makes plays. It seems to not even matter who's covering him. He's going to find a way to make plays and we've just got to hopefully slow him down a little bit. He's a great player."
Said Whitt: "He's very hard on little guys because little guys can't bring him down. He's very hard on big guys because he can separate from them. So he's a dynamic player, and he plays with a great play speed and effort."
That sounds like what defenders used to say about former Packers tight end Jermichael Finley.
"I think you could say that," Whitt said. "He's a matchup issue; he really is."
So who will it be on Gronkowski?
"There could potentially be some opportunities in the game where I'm matched up against him," Matthews said this week. "Yeah, we'll see. Obviously, I enjoy those opportunities to kind of showcase my talents, especially at something that is not my normal pass rushing."
"I didn't go to the coach and say, 'I want him,' but at the same time I think it will be fun," Hyde said. "Whoever is lined up against him, I have confidence in any one of our guys that lines up against him, and it's going to be a good opportunity."
And don't forget about outside linebacker Julius Peppers, who has dropped into coverage more this year than in perhaps his first 12 NFL seasons combined. He has a pair of interceptions, both returned for touchdowns, to show for it.
"I've had a little success with it this year," Peppers said. "It's something that I wanted to do, and I've been able to do it since I've been here."