The Sun Devils erupted early and left little doubt. It helped that they forced five turnovers and gave away just one, a fumble that was returned for a TD.
ASU now has now has forced 25 turnovers this season, most by far in the Pac-12.
Colorado QB Tyler Hansen came off the bench and threw for 321 yards, but he had two interceptions.
Arizona State improves to 6-2 and 4-1 in the conference. It visits UCLA next weekend.
Colorado falls to 1-8 and 0-5. It hosts USC.