Price, who started the season slowly, and the Huskies continued their upswing. They can post their first eight-win season since 2001 with a win at Washington State next week.
Price completed 22 of 29 passes for 248 yards with no interceptions.
The Buffaloes' (1-10, 1-7) woes continued. Connor Wood started at quarterback, but he was pulled after completing 3 of 6 passes for 11 yards with two interceptions. The Buffs were outgained 476 yards to 141, and they surrendered five turnovers.
With a loss to Utah on Friday, Colorado will finish with the worst record in school history.