Mathews has been nursing a lingering ankle issue for the past three weeks.
For the past two weeks, Mathews has not practiced on Wednesday and Thursday, worked as a limited participant on Friday and played in the game on Sunday.
Hardwick re-aggravated a neck stinger that he’s been battling during the second half of the season in Sunday's game at Cincinnati, while Fluker is dealing with an ankle issue.
Royal has a toe injury that he’s played with since suffering the injury against Indianapolis on Oct. 14. Weddle’s absence appears to be more of a rest day for the 29-year-old veteran.