Must happen: Stick to their game plan. The 49ers are one of the best teams in the NFL. They run the ball on offense and they stop the run on defense. They need to just play their game and they should be fine. The Panthers are hot and dangerous. But San Francisco is the better team and if the 49ers stay the course they should extend their win streak to six games with big games against the New Orleans Saints and the Seattle Seahawks looming.
Must not happen: Turn the ball over often. The 49ers have done a good job of protecting the ball this season, especially during their five-game win streak. If the Panthers can force some turnovers, it will put the ball in the hands of this hot offense more than the 49ers want. The Panthers are averaging 32 points a game during a current four-game win streak. The 49ers can’t give the Panthers any gifts.