Injuries could be issue this week for 49ers

The San Francisco 49ers’ 53-man roster was pretty healthy in the first two weeks of the season. However, the 49ers limped out of their 29-3 defeat at Seattle.

Nose tackle Ian Williams broke his ankle and was lost for the season. We may see the effects of the loss at practice this week. Standout tight end Vernon Davis tweeted late Tuesday night that he needs to rest his hamstring, which was injured late against the Seahawks, but he should be able to play Sunday against Indianapolis. It probably means he will not practice much this week.

Davis could have some company on the sideline. Defensive end Ray McDonald left in the fourth quarter, but X-rays on his right ankle were negative. He could also miss some time this week in practice, at least.

Safety Eric Reid, who has been outstanding in his first two NFL games, missed the second half Sunday because of a potential concussion. San Francisco coach Jim Harbaugh said Monday that Reid did not show any concussion symptoms. He will need to pass the NFL’s concussion test to play Sunday.

Running back LaMichael James has missed the first two games with a knee sprain. There is a chance he returns to practice this week.