Harbaugh, the 49ers’ coach, coached Luck, one of the brightest young quarterbacks in the league, at Stanford. However, it isn’t the only reunion during the game.
San Francisco tight end Vernon Davis will face his younger brother Vontae Davis, who is a Colts’ cornerback. It will be the first time the two brothers will meet. Davis was drafted by Miami in 2009 and traded to the Colts last year.
The Colts also have Cam Johnson. The 49ers traded him to the Colts earlier this month for a seventh-round pick in 2015. He was a stout in the preseason but fell victim to a numbers’ game. He does not have a tackle in two games with the Colts.