Left tackle Bradley Sowell has not started a game since 2013. Left guard Mark Glowinski has one career start. Justin Britt is playing center for the first time. Right guard Germain Ifedi is a rookie. And right tackle has been a question mark all summer.
Keeping that in mind, here are six players to watch, courtesy of ESPN Dolphins reporter James Walker:
QB Ryan Tannehill: The Dolphins and Seahawks have something in common in that they both drafted their starting quarterbacks in 2012. Miami took Tannehill No. 8 overall in the same year Seattle selected Wilson in the third round. Tannehill is coming off back-to-back 4,000 yard seasons but has yet to post a winning season.
WR Jarvis Landry: The Pro Bowl receiver is Miami’s most consistent player. He set a team record with 110 receptions last year and is easily the Dolphins’ most targeted receiver. Most of Landry’s damage is done in the slot.
RB Arian Foster: The Dolphins are relying on the former Pro Bowl running back to provide stability and versatility to the running game. Foster, who just turned 30, showed he still has something left in the tank during the preseason.
DT Ndamukong Suh: Miami’s best and highest-paid player is a force in the middle of the defense and should pose major problems for Seattle’s inconsistent offensive line. Suh is very tough to block one-on-one and often faces double teams. That frees up others in the front seven to make plays.
DE Mario Williams: The Dolphins signed Williams in free agency in hopes that he can revert back to his Pro Bowl form. Williams had double-digit sacks in 2013 and 2014 before suffering a down season last year.
DE Cameron Wake: Notice a theme here? Miami’s defensive line is deep with talented defenders and is arguably the strongest area of the team. Wake had seven sacks in seven games last year before suffering a season-ending Achilles injury. His job Sunday will be to disrupt Wilson on passing downs.