The Cardinal now await the outcome of games next week before finding out their postseason destination -- which more than likely will include an at-large bid to a BCS game.
Luck and Fleener also hooked up for a 28-yard touchdown in the first half.
Senior Night quickly turned into Andrew Luck night as the Heisman Trophy candidate set the Stanford record for most career touchdown passes (80) and the single-season mark (35). Luck finished the game 20-of-30 for 233 yards, four touchdowns and an interception.
Notre Dame turned the ball over three times and never really found a rhythm on offense, switching between quarterback Tommy Rees in the first half to Andrew Hendrix in the second half. Hendrix and Michael Floyd hooked up for a 6-yard touchdown strike in the third quarter.
The Cardinal’s relentless pass rush sacked Notre Dame’s quarterbacks five times -- it was the fourth time this season Stanford has had five or more sacks in a game.