Despite giving up an unearned run in the first inning, he ended the day by throwing the third no-hitter of the season.
It was the ninth no-hitter in franchise history and the first since Mark Langston and Mike Witt combined on a no-hitter against the Seattle Mariners in 1990.
Santana's first MLB start came on May 17, 2005 at Cleveland. He allowed eight hits and six runs and took the loss in a 13-5 defeat.
In that game, in the bottom of the first, the first four batters Santana faced hit for the cycle.
He was the first pitcher since the start of divisional play in 1969 to allow a "cycle" to the first four batters he faced in his career. He was also the first pitcher since the start of divisional play to allow that combination of hits (triple, double, single, home run) to the first four batters he faced.
Most No-Hitters Since 1961
Santana –- who struck out a season-high 10 –- had a Game Score of 94, tied for the highest of the season. (Game Score, a metric devised by Bill James, assigns a pitcher points using innings pitched, strikeouts, hits, walks, and runs).
Both Game Scores of 94 have come against the Indians. (Justin Verlander had a 94 against Cleveland on June 14 when he threw a two-hit shutout and struck out 12).
SOME OTHER NOTES FROM SANTANA'S NO-NO:
• Ted Barrett was the umpire on Wednesday, the second no-hitter he's called in his career. The other was New York Yankees pitcher David Cone's perfect game against the Montreal Expos on July 18, 1999.
• As for the Indians, it’s the first no-hitter thrown against them since Jim Abbott on September 4, 1993 for the Yankees, and the first no-hitter at Progressive Field.
• Members of the Indians were 0-19 against Santana's fastball Wednesday with five strikeouts. Entering the game, the Indians were batting .290 against fastballs during the month of July, fourth in the AL and 10th overall in that span.
• There have been nine no-hitters since the start of last season (including postseason). There were eight no-hitters thrown from 2005-2009 total.
• Santana carried a no-hitter into the sixth inning of his last start (July 22 at Baltimore) before allowing a double to Blake Davis with one out in the sixth inning (5.1 innings). Santana and Verlander are the only players to carry no-hit bids into the sixth inning of consecutive starts this season and both threw a no-hitter in one of the two starts.
• Santana generated 14 swings-and-misses on Wednesday. That is his most in any start since September 27, 2010 against the Oakland Athletics where he also posted 14.