The 49ers moved to 3-1 despite being outgained by 349 yards this season. The Eagles dropped to 1-3.
It's the fourth time in franchise history (and first time since 1999) the Eagles lost a game which they led by at least 17 at halftime. They led by exactly 17 at the half against San Francisco on Sunday.
According to the Elias Sports Bureau, the Eagles are the fourth team since 2000 to lose three straight games in which they led entering the fourth quarter in each, joining the 2006 Oakland Raiders, the 2009 Washington Redskins, and this season’s Minnesota Vikings.
The last team to lose four straight such games was the 1999 Saints.
The Eagles have now dropped three in a row in the regular season for the first time since the 2007 season (Weeks 12-14).
Philadelphia gained a season-high 513 yards, but has now been outscored 36-0 in the fourth quarter the past three weeks.
Michael Vick passed for a career-high 416 yards, the first 400-yard game of his career. But he threw his third interception of the season; he didn't throw his third interception last season until Week 13.
Vick Targeting Jackson
15+ Yards Downfield, 2011 Season
Philly’s passing game did feature DeSean Jackson more than in weeks past. Jackson finished with 171 receiving yards, connecting with Vick on throws of 15+ yards downfield four times for 154 yards.
Entering Sunday, they connected just twice on such throws this season.
On the other side of the ball, the Eagles interior run defense continued to be exposed. They entered Sunday allowing the most yards in the league on runs of the middle, at 6.2 yards per rush.
Frank Gore Up The Middle
Frank Gore found similar success, to the tune of 13 rushes for 109 yards on carries aimed at the Philly interior, including the game-winning touchdown.
49ers quarterback Alex Smith also took advantage of a Philly defense that didn’t offer up much in terms of pressure.
The Eagles sent four or fewer pass rushers on 30 of 36 dropbacks (83.3 pct). Smith went 18-28 for 247 yards and a touchdown in those situations.
Coming into the game, Smith had the second-fewest passing yards against fewer than five rushers in the NFL.