Ortiz had been out since Aug. 14 because of bursitis in his right heel. He went 2-for-5 with an RBI as the Red Sox beat the Rangers 13-2.
"You could tell he was ready (Tuesday) night. He was starting to get loud and obnoxious. Actually the medical people said he could have pinch-hit (Tuesday) night, but there was no reason to," said Red Sox manager Terry Francona.
Ortiz ran for approximately five minutes on the outfield grass Tuesday afternoon under the watchful eye of head trainer Mike Reinold. Afterward Ortiz deemed himself ready to go.
"He did really well running and that's what we wanted him to do. We didn't want him to go out there and limp and play a game too early, or go backwards," Francona said. "He looks fine."
Also, right-hander Bobby Jenks, out since July 8 with back tightness, is scheduled to pitch in a minor league game Saturday. Francona said Jenks could rejoin the Red Sox by the end of next week.
Due to the pending hurricane, the Red Sox are still trying to figure out where the right-hander will pitch.
"They're going to get it figured out, but it will be Saturday," said Francona. "He's been getting after it pretty good."
If everything goes well, Jenks will likely need another minor league appearance and could be activated from the DL on or slightly after Sept. 1, Francona said.
Also, J.D. Drew has returned to Boston and is scheduled to take batting practice Thursday at Fenway Park.
Drew, who has been on the disabled list with an impingement in his left shoulder, is set to begin a four game minor league rehab assignment Friday with Single-A Lowell. If all goes well after he completes his rehab, he could be activated next Thursday.
Kevin Youkilis is expected to begin baseball activities when the team returns home this weekend.
He remained in Boston while the Red Sox went on a road trip and started to ramp up his cardio activity the last couple of days.
Youkilis is eligible to come off the DL on Sept. 1 and Francona doesn't believe the veteran infielder will need to make a minor league rehab assignment.
"I doubt it," Francona said. "I don't know. If he needs it we'll do it, but I doubt it."
Joe McDonald covers the Red Sox for ESPNBoston.com. Information from The Associated Press was used in this report.