Catcher Ryan Lavarnway, recalled from Triple-A Pawtucket on Thursday, was optioned to make room on the roster for Lackey.
Lavarnway did not appear in a game for the Sox.
It will be the first start in Fenway Park for Lackey since Sept. 19, 2011, when he gave up eight runs on 11 hits in 4 1/3 innings against Baltimore. The right-hander missed all of 2012 following Tommy John surgery, then suffered a right biceps strain in his first start of the season April 6 in Toronto.
Manager John Farrell said he hopes to get five innings from Lackey, who threw 70 pitches against the Blue Jays before the injury and 67 in a rehab outing Monday for Double-A Portland.
Lavarnway hit .310 (13-for-42) with a home run, three doubles and seven RBIs while with Pawtucket prior to the recall.
Tony Lee is a regular contributor to ESPNBoston.com.