Celtics coach Doc Rivers said O'Neal could either be sidelined for Boston's entire upcoming four-game road trip (Oklahoma City, Dallas, Miami, and Memphis), or he could be back in time for Friday's game against Chicago.
"I figured I'd cover all my bases," Rivers joked.
With 77 games in front of them, the Celtics will not rush O'Neal back before he's ready and risk injuring him worse. The knee remains sore and O'Neal suggested earlier this week that he won't be able to get back on the floor until that soreness allows him to push off without pain.
"He's not going to play [Wednesday] and I don't know if he'll even play on this upcoming trip," said Rivers. "We don't know that, but just watching him move, he didn't move very well [during Wednesday's team walk-through]."
Rivers said Jermaine O'Neal would start in his place.
Chris Forsberg covers the Boston Celtics for ESPNBoston.com. Information from The Associated Press was used in this report.