Week 15: 49ers 41, Patriots 34
Photograph By Jared Wickerham/Getty Images
The Niners ultimately ended the Patriots' seven-game winning streak, but not before Brady led New England on a 28-point comeback. The Patriots tied it at 31 (after trailing 31-3), but they gave up a long return on the ensuing kickoff and the Niners scored to go up for good. Brady had 443 yards passing but was picked off twice.