Unified flyweight titleholder Juan Francisco Estrada will defend his two belts against Mexican countryman and former titleholder Hernan "Tyson" Marquez on Sept. 26 at the Puerto Penasco Convention Center in Puerto Penasco, Mexico, Zanfer Promotions announced on Thursday.
It will be a hometown fight for Estrada, who was born in Puerto Penasco.
The fight, which has been talked about for the past couple of years, will be televised in the United States on beIN Sports Espanol.
Estrada (32-2, 23 KOs), 25, will be making his fifth title defense since outpointing Brian Viloria to win both belts in April 2013. He is coming of a third-round knockout win of Rommel Asenjo to retain the belts on March 28.
There had been talk that Estrada might fight flyweight champion Roman Gonzalez in a unification fight -- and a rematch of Gonzalez's successful strawweight title defense in 2012 -- but Gonzalez is giving a shot to Viloria on Oct. 17.
Marquez (39-5-1, 28 KOs), 26, who lost his flyweight world title by 10th-round knockout to Viloria in their 2012 unification fight, has won two bouts in a row. Marquez said he is excited to get another world title opportunity.
"I'm convinced it's a great fight against a great champion, but I feel very confident," Marquez said at Thursday's news conference. "I am convinced it will be a great fight, although many people do not give me a chance to win. But the negative comments motivate me to prepare more to give a great fight."