Kal Yafai's promoter Eddie Hearn says the Briton can set up a world super-flyweight title unification fight with victory over David Carmona on Saturday night.
WBA champion Yafai (23-0, 14 KOs), 28, from Birmingham, makes a third title defence on the same bill as IBF titleholder Jerwin Ancajas, who faces Jonas Sultan in the first all-Filipino world title fight in 93 years in the main event at the Save Mart Center in Fresno, California.
And Hearn is confident a clash with the winner of Ancajas-Sultan awaits for Yafai if he can overcome Mexican Carmona (21-5-5, 9 KOs), 27, on his U.S. debut which will be streamed live exclusively on ESPN+.
"This is a really important fight for Kal and I was very keen for him to take this fight," Hearn told ESPN.
"It's something different, it exposes him to a new audience and the most lucrative market for him in this division is in America. It's a very popular market in the U.S. and there are a lot of opportunities for him there.
"He's going to make a good statement and people are going to start talking about him fighting the likes of Ancajas, [WBC champion Srisaket Sor] Runvisai and you've also got the likes of [Juan Francisco] Estrada and Roman Gonzalez.
"All of the champions are targets. Sooner or later he's going to jump in with a champion and he will have to try and unify the division. You could also see him move up to bantamweight in time."
Ancajas (29-1-1, 20 KOs), 26, will be making a fifth defence of the IBF title against Sultan (14-3, 9 KOs), also 26. Ancajas is being compared to Manny Pacquiao, the Filipino who has won world titles in eight weight divisions, and impressed British fans when he stopped Jamie Conlan in Belfast in November.
Pancho Villa and Clever Sencio were the last two boxers from the Philippines to fight for a world title on May 2, 1925, in Manila. Villa retained his world flyweight title by a unanimous 15-round points decision in his penultimate fight and two months before his sudden death, aged 23, due to an infection from a tooth extraction.
The bouts will take place on the first Top Rank-promoted card to stream live exclusively on ESPN+. The entire card will stream live beginning at 6:30 p.m. (11:30 p.m. BST) ET, with coverage of the title fights slated to start at 9:30 p.m. (02:30 a.m.) ET.