CG Technology released lines for every NFL game in Weeks 1-16 this week. Below, we'll run through the 10 games with the biggest spreads of the season.
This marks the largest opening spread of the season, and one of four games in which Seattle is favored by double digits. The 49ers, along with the Cleveland Browns, are one of two teams that aren't favored in a game this season (San Francisco is a pick-em in three games). Last season, when these teams met in Seattle, the Seahawks won by 13 as a 14-point favorite, their fourth straight double-digit home win over San Francisco.
Week 2: San Francisco 49ers at Carolina Panthers (-11.5)
The week before going to Seattle, the 49ers play on the opposite coast as 11.5-point underdogs at Carolina. Just like the Seahawks, this is one of four games that the Panthers are a double-digit favorite in. Last season, the Panthers were the only team that went undefeated at home, outscoring their opponents by 16 PPG in Carolina.
Week 7: Cleveland Browns at Cincinnati Bengals (-11.5)
This is the only game that an AFC team opened as a double-digit favorite. The Browns -- who are the biggest longshot to win the Super Bowl at 200-1 -- are, as mentioned, the only team that is currently listed as an underdog in every game. Last season when these teams met in Cincinnati, the Bengals won by 21 as a 13-point favorite.
Week 10: San Francisco 49ers at Arizona Cardinals (-10.5)
In Week 3 last season, the Cardinals closed as a 7-point home favorite against the 49ers. Arizona would win that game, 47-7, by far its largest margin of victory over San Francisco in franchise history. The Cardinals however, haven't covered as a double-digit favorite since 2009 (2-0 SU, 0-2 ATS with both games coming last season).
Week 5: Tampa Bay Buccaneers at Carolina Panthers (-10)
This marks the first of two Monday Night Football games with a double-digit spread this season. A year ago, there were three MNF games with a spread of at least 10 points, with the underdog covering every time. As for this matchup, the Panthers are 6-0 against the Buccaneers since 2013, winning those games by an average of 14.8 PPG.
Week 6: Atlanta Falcons at Seattle Seahawks (-10)
The Seahawks are favored by at least 10 in half of their home games in 2016. Last season, Seattle covered in three of the five games it closed as a double-digit favorite. Entering 2016, the Falcons have been a double-digit underdog four times since drafting Matt Ryan, covering in each game (0-4 SU).
Week 9: Buffalo Bills at Seattle Seahawks (-10)
This is just the second Monday Night Football game for the Bills in the last seven seasons, and once again they face a tough road test (they lost by 7 as a 7-point underdog last season at New England). If the Bills can pull the upset in Seattle, it would be their first win on MNF since they beat Dan Marino and the Dolphins in 1999.
Week 11: New Orleans Saints at Carolina Panthers (-10)
For the second straight season, the Panthers are a 10-point home favorite over the Saints. New Orleans was without Drew Brees in that game, and the 2016 line is based on the assumption he will play. If he plays and the line doesn't drop, it will mark the first time the Saints are a double-digit underdog in a regular season game with Brees.
Week 14: San Diego Chargers at Carolina Panthers (-10)
This will be the first time that the Chargers play at Carolina since 2004, when Drew Brees was their starting quarterback (San Diego won by 11 as a 3-point 'dog). Including that game, the underdog has won the last three meetings outright between these teams.
Week 15: Los Angeles Rams at Seattle Seahawks (-10)
The Rams won both meetings last season, with each win coming as the underdog. This includes Week 16, when they won 23-17 in Seattle as an 11.5-point 'dog. That marked the biggest pointspread upset of the 2015 season.