Here is a look at some things to know as you bet the Week 3 games.
All lines are courtesy of Westgate Las Vegas SuperBook, and all games are on Sunday unless otherwise specified.
Baltimore Ravens (-3.5, 39.5) vs Jacksonville Jaguars, 9:30 a.m. ET (London)
Cleveland Browns (-1.5, 41) at Indianapolis Colts, 1 p.m. ET
This will mark just the ninth time the Browns are favored on the road since returning to the NFL in 1999, which is 15 fewer games than any other team.
Under Chuck Pagano, the Colts are 9-2 ATS with seven outright wins as a home underdog.
The under is 8-2 in Cleveland's past 10 games. Six straight games played in Indianapolis have gone under the total.
Pittsburgh Steelers (-7.5, 44) at Chicago Bears, 1 p.m. ET
Under John Fox, the Bears are 1-7 ATS and 0-8 SU in games played in September.
The under is 17-5 in Pittsburgh's past 22 road games.
Miami Dolphins (-6, 43) at New York Jets, 1 p.m. ET
In Adam Gase's first season as head coach in 2016, the over hit in all six of Miami's divisional games.
The Jets are 8-2 ATS with six outright wins in their past 10 games as a home underdog against the Dolphins.
Denver Broncos (-3, 40) at Buffalo Bills, 1 p.m. ET
Houston Texans at New England Patriots (-14, 44), 1 p.m. ET
New Orleans Saints at Carolina Panthers (-5.5, 46.5), 1 p.m. ET
Tampa Bay Buccaneers (-2.5, 39.5) at Minnesota Vikings, 1 p.m. ET
Atlanta Falcons (-3, 50.5) at Detroit Lions, 1 p.m. ET
New York Giants at Philadelphia Eagles (-6, 42.5), 1 p.m. ET
Carson Wentz is 6-2 ATS at home in his career, compared to 3-7 ATS on the road.
The under is 6-1 in the past seven meetings between these teams in Philadelphia.
Seattle Seahawks at Tennessee Titans (-2.5, 42), 4:05 p.m. ET
Kansas City Chiefs (-3, 47.5) at Los Angeles Chargers, 4:25 p.m. ET
Cincinnati Bengals at Green Bay Packers (-9, 46.5), 4:25 p.m. ET
Oakland Raiders (-3, 55) at Washington Redskins, 8:30 p.m. ET
Dallas Cowboys (-3, 47) at Arizona Cardinals, 8:30 p.m. ET (Monday)
Since University of Phoenix Stadium opened in 2006, Arizona has the most wins in the league as a home underdog, having won outright 19 times in 32 games (21-11 ATS).
The under is 10-2 in Arizona's past 12 home games.