Here is a look at some things to know as you bet the weekend slate of Week 5 college football games.
All lines are courtesy of Westgate Las Vegas SuperBook, and all games are on Saturday unless otherwise specified.
Miami Hurricanes (-6.5, 56) at Duke Blue Devils -- 7 p.m. ET (Friday)
Duke is 6-0 ATS with four outright wins in their last six games as a home underdog.
Duke is one of four FBS teams that have gone 4-0 ATS so far this season (New Mexico State, SMU and Utah are the others).
USC Trojans (-3.5, 64) at Washington State Cougars -- 10:30 p.m. ET (Friday)
Northwestern Wildcats at Wisconsin Badgers (-15.5, 49) -- 12 p.m. ET
Vanderbilt Commodores at Florida Gators (-9.5, 42) -- 12 p.m. ET
Indiana Hoosiers at Penn State Nittany Lions (-18.5, 63.5) -- 3:30 p.m. ET
This will mark Penn State's third game with an over/under in the 60s this season, with the previous two both going under. In the last 18 seasons prior to 2017, the Nittany Lions played in two games with an over/under in the 60s.
Georgia Bulldogs (-7.5, 47) at Tennessee Volunteers -- 3:30 p.m. ET
Florida State Seminoles (-7.5, 47) at Wake Forest Demon Deacons -- 3:30 p.m. ET
Since the start of last season, Wake Forest is 7-1 ATS with four outright wins as an underdog.
The under is 8-2 in Florida State's last 10 road games.
Iowa Hawkeyes at Michigan State Spartans (-3.5, 43.5) -- 4 p.m. ET
Mississippi State Bulldogs at Auburn Tigers (-9, 52.5) -- 6 p.m. ET
Troy Trojans at LSU Tigers (-20.5, 49) -- 7 p.m. ET
Ohio State Buckeyes (-30.5, 54) at Rutgers Scarlet Knights -- 7:30 p.m. ET
Clemson Tigers (-7.5, 51) at Virginia Tech Hokies -- 8 p.m. ET
Oklahoma State Cowboys (-9.5, 85.5) at Texas Tech Red Raiders -- 8 p.m. ET
The over is 4-0-1 in the last five meetings between these teams.
Since Mike Gundy became Oklahoma State's head coach in 2005, the Cowboys are 8-3-1 ATS against Texas Tech.
Ole Miss Rebels at Alabama Crimson Tide (-27.5, 59.5) -- 9 p.m. ET
Northern Illinois Huskies at San Diego State Aztecs (-11, 47.5) -- 10:30 p.m. ET
Colorado Buffaloes at UCLA Bruins (-7, 68) -- 10:30 p.m. ET
California Golden Bears at Oregon Ducks (13.5, 68.5) -- 10:30 p.m. ET