Here is a look at some things to know as you bet the Week 4 games.
All lines are courtesy of Westgate Las Vegas SuperBook, and all games are on Sunday unless otherwise specified.
New Orleans Saints (-3, 50.5) vs Miami Dolphins - 9:30 a.m. ET (London)
Pittsburgh Steelers (-3, 42.5) at Baltimore Ravens - 1 p.m. ET
The Ravens are 4-0 ATS with three outright wins in their past four games as an underdog against the Steelers.
The Ravens are 9-2 ATS in their past 11 divisional games.
In its past seven games an underdog in divisional games, Baltimore is 7-0 ATS with five outright wins.
The under is 18-5 in Pittsburgh's past 23 road games.
Buffalo Bills at Atlanta Falcons (-8, 48.5) - 1 p.m. ET
Carolina Panthers at New England Patriots (-9.5, 49.5) - 1 p.m. ET
The total has gone over in seven straight Patriots games.
This will mark the 12th game started by Cam Newton that the Panthers are underdogs of at least seven points. The over is 10-1 in the previous 11 games.
Los Angeles Rams at Dallas Cowboys (-6.5, 48.5) - 1 p.m. ET
Detroit Lions at Minnesota Vikings (-2, 42.5) - 1 p.m. ET
Tennessee Titans (-2.5, 44) at Houston Texans - 1 p.m. ET
Jacksonville Jaguars (-3.5, 38) at New York Jets - 1 p.m. ET
Cincinnati Bengals (-3, 41.5) at Cleveland Browns - 1 p.m. ET
New York Giants at Tampa Bay Buccaneers (-3, 44.5) - 4:05 p.m. ET
Philadelphia Eagles at Los Angeles Chargers (-1.5, 47.5) - 4:05 p.m. ET
San Francisco 49ers at Arizona Cardinals (-7, 44.5) - 4:05 p.m. ET
Oakland Raiders at Denver Broncos (-3, 46) - 4:25 p.m. ET
Indianapolis Colts at Seattle Seahawks (-13, 41.5) - 8:30 p.m. ET
Washington Redskins at Kansas City Chiefs (-7, 49.5) - Monday at 8:30 p.m. ET