Here is a look at some things to know as you bet the weekend slate of Week 6 college football games.
All lines are courtesy of Westgate Las Vegas SuperBook, and all games are on Saturday unless otherwise specified.
Wake Forest Demon Deacons at Clemson Tigers (-21.5, 47.5) - 12 p.m. ET
Iowa State Cyclones at Oklahoma Sooners (-28, 68.5) - 12 p.m. ET
Penn State Nittany Lions (-14.5, 53) at Northwestern Wildcats - 12 p.m. ET
Since the start of the 2014 season, Northwestern is 7-0 ATS with five outright wins as a double-digit underdog. This includes a 29-6 win at Penn State as a 10.5-point underdog in 2014.
The total has gone under in four of Penn State's five games this season. In 2016, the total went over in 10 of the Nittany Lions' 14 games.
Georgia Bulldogs (-17.5, 40.5) at Vanderbilt Commodores - 12 p.m. ET
West Virginia Mountaineers at TCU Horned Frogs (-13.5, 68.5) - 3:30 p.m. ET
Miami Hurricanes (-3, 46.5) at Florida State Seminoles - 3:30 p.m. ET
Notre Dame Fighting Irish (-14.5, 59) at North Carolina Tar Heels - 3:30 p.m. ET
LSU Tigers at Florida Gators (-2.5, 45.5) - 3:30 p.m. ET
Air Force Falcons at Navy Midshipmen (-7.5, 53) - 3:30 p.m. ET
Since 2012, the under is 12-1-2 in Commander-in-Chief's Trophy games (games between Air Force, Army, Navy). The under is 5-0 in games between Air Force and Navy during this span.
Maryland Terrapins at Ohio State Buckeyes (-31, 60.5) - 4 p.m. ET
Kansas State Wildcats at Texas Longhorns (-3.5, 50) - 7 p.m. ET
Alabama Crimson Tide (-26.5, 54) at Texas A&M Aggies - 7:30 p.m. ET
Michigan State Spartans at Michigan Wolverines (-10.5, 40) - 7:30 p.m. ET
Under Mark Dantonio, Michigan State is 3-0 ATS with two outright wins as an underdog at Michigan Stadium. This includes a 27-23 win as a 7.5-point underdog in the Spartans' last trip to Ann Arbor.
The over is 10-3 in Michigan State's last 13 games as an underdog.
Washington State Cougars (-2.5, 62) at Oregon Ducks - 8 p.m. ET
Wisconsin Badgers (-11.5, 45.5) at Nebraska Cornhuskers - 8 p.m. ET
UCF Knights (-17, 55) at Cincinnati Bearcats - 8 p.m. ET
Stanford Cardinal (-5.5, 50.5) at Utah Utes - 10:15 p.m. ET
California Golden Bears at Washington Huskies (-27.5, 56.5) - 10:45 p.m. ET