Northern Illinois will host the Cornhuskers in Chicago on Sept. 24, 2016, and the Huskies will play at Nebraska on Sept. 2, 2017 and Sept. 14, 2019.
Northern Illinois has played Big Ten competition at Soldier Field the past two years.
The Huskies lost to Wisconsin before 41,068 fans in 2011 and fell to Iowa before a crowd of 52,117 this season. Their 18-17 loss to Iowa was their only defeat this season.
"Ever since the Iowa game this past September, I've been asked about the next Huskie home game at Soldier Field," Northern Illinois athletic director Jeff Compher said in a statement. "I am very pleased to announce this 2016 game in Chicago with Nebraska, one of the most storied programs in college football.
"The benefits of playing at Soldier Field cannot be overstated. It's a beautiful NFL venue that allows us to showcase our team and program to recruits, and to connect with our alumni base in the city. We are so grateful to be able to continue this partnership with the city of Chicago, the Park District and Tim LeFevour and his SMG team."
Northern Illinois and Nebraska last played on Sept. 8, 1990; the Cornhuskers won 60-14.
Nebraska also defeated the Huskies 48-17 on Sept. 9, 1989.
Northern Illinois is preparing to face Florida State in the Discover Orange Bowl on Jan. 1. The Huskies earned a place in the BCS by finishing No. 15 in the BCS standings and ahead of Big Ten champion Wisconsin and Big East champion Louisville. Northern Illinois went 12-1 overall (8-0 in the MAC) and is riding a 12-game winning streak.