Pierzynski, 34, goes to the disabled list for the first time in his 14-year career. He suffered the injury on Friday when he was hit by a pitch from Kansas City's Bruce Chen.
The veteran could be out as little as two weeks if all goes well. Trainer Herm Schneider said that although the injury is being called a fracture it's more like a severe bone bruise which could lead to a faster healing time. Pierzynski, who was wearing a brace on his wrist Monday, will be fitted for a hard cast.
"Knowing me, I'd try to play today and go, but they're basically doing this to keep me out of my own harm's way," Pierzynski said. "Hopefully we're going to re-test it in 10 days and if it's better then hopefully I'll be ready to go."
The move is retroactive to Aug. 13, making Pierzynski eligible to be activated Aug. 28. He says he hopes to be ready by Sept. 1.
Pierzynski, who is batting .296 with six home runs and 39 RBIs, leads American League catchers in games played (103) and innings caught (862 1/3).
An MRI on Monday night confirmed the original diagnosis of bone trauma but technically no break. Because of the severity and the fact that Pierzynski wasn't getting any better, it prompted the White Sox to upgrade the injury to a fracture and put the catcher on the DL. Technically, Pierzynski has a bone compression.
The White Sox, who open a series against the Cleveland Indians at U.S. Cellular Field on Tuesday, recalled catcher Donny Lucy from Triple-A Charlotte. He joins rookie Tyler Flowers as the only catchers on the roster. Veteran backup Ramon Castro was lost for the season in July with a broken right hand and index finger.
"I have to prepare myself each day for whoever is pitching for us and for whoever is pitching for them and do the best I can," Flowers said. "You can't put any more pressure on it than that. I don't think A.J. or Castro is going to come back to take my job in the next week, so I have a little time. Nothing to worry about. Just play my game and do the best I can."
Pierzynski is confident that Flowers will be a more than adequate fill-in while he recovers.
"He's been up and down a couple times. This isn't his first time here, he's comfortable around the guys," Pierzynski said. "He's just thrust into a new situation where he and Lucy are gonna be out there every day and they have to figure it out. (Pitching coach Don Cooper) will do a good job of keeping them informed on what we want to do."
Lucy, 29, was hitting .158 with four home runs and nine RBIs at Charlotte.
"This is my eighth year with the organization (and) I know a lot of the guys here," Lucy said. "I know a lot of the pitchers and then being in spring training all the way to the end, that definitely helps too, being more comfortable with the team. It's definitely nice. It's a more comfortable transition."
Doug Padilla covers the White Sox for ESPNChicago.com. Information from The Associated Press was used in this report.