At 9:36 of the first quarter, Rose was bumped going in for a layup by Dwight Howard, lost his balance and landed awkwardly on his back. After being tended to on the floor, he made a free throw to complete a three-point play and then walked gingerly to the locker room.
X-rays taken at the arena showed no structural damage, Rose went for an MRI and was unavailable for comment.
"He had X-Rays here at the United Center and was examined by our doctors from Rush," trainer Fred Tedeschi said. "And he was pretty sore and stiff. Couldn't finish the game. So, given what's coming up this weekend we decided to get an MRI on him, and he's over at Rush Medical Center getting that right now. We won't know the results until later on [Wednesday night]. Anything beyond that we don't know. We're just getting a precautionary MRI."
The Magic went on a 9-0 run immediately after Rose left and went on to a 41-17 lead after one quarter. They coasted to a 107-87 win.
In his second year, Rose earned his first All-Star selection and is scheduled to defend his Skills competition title during All-Star Weekend. Now it's wait and see time.
"I'm not sure we've completely ruled out a fracture but it looks unlikely at this point," Tedeschi said. "From there I guess it's exotic things it could be, but you saw what happened. He fell ... he was wearing the Adidas compadded shorts and I think that probably soaked up a lot of the blow. Hopefully, it's going to turn out to be not as bad as it could have been."
The Bulls were already without starting center Joakim Noah, who is third in the league in rebounding at 12.0 per game, due to a foot injury.
ESPNChicago.com's Nick Friedell contributed to this report.