Rose did not participate in the morning shootaround and did not play in Wednesday's victory over the Miami Heat.
This is the 12th game Rose missed this season with turf toe, back spasms and now the groin pull. Many believe Rose should rest more to have him as fresh as possible for the postseason, but coach Tom Thibodeau does not subscribe to that theory.
"I think again that's what you guys think," Thibodeau said. "I'm fortunate because I get to see what these guys can do every day.
"It doesn't surprise me. Obviously, we'd prefer to have everybody. But it's part of the game and it's how you deal with all those things that come your way. Injuries are part of it. Every team goes through it. It's how you handle those challenges as they come forward that determines a big part of your success."
Thibodeau said Rose wouldn't necessarily practice before getting back into a game, but wasn't sure he'd be back against the 76ers on Saturday.
"[He's] day to day," Thibodeau said before Friday's game. "[We'll] just see where he is. We just want him to make steady improvement. And when he's ready to go, he'll go."
C.J. Watson started, after being a game-time decision. Luol Deng, who has been dealing with a sore wrist but returned to action against the Heat, participated in shootaround and was also in the starting lineup.
"Lu's good, he's going," Thibodeau said before the game.
ESPNChicago.com's Nick Friedell contributed to this report.